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Form 1099-OID is used to report a special type of interest from certain bonds that were issued at a price less than the value you can redeem them for once the bond matures. Here's what you need to know about this type of interest and tax form.

Form 1099-OID, Original Issue Discount, exists to report income when bonds, notes, or certificates of deposit (CDs) are sold at a discount from their maturity value. For example, a bond with a $1,000 face value may be sold for $900. When the bond matures, the bondholder will receive the full $1,000 despite only paying $900 for it. The taxpayer captures the discount as income over the life of the instrument rather than waiting until it is sold.

TikTok on Wednesday announced several updates intended to help users customize their viewing preferences and filter out content that may be problematic or too mature for young users, amid renewed scrutiny of the potential harms social media poses to teens.

TikTok also said it is rolling out a new system that organizes content based on thematic maturity, not unlike the ratings systems used in film and television. The new safeguards will allocate a "maturity score" to videos detected as potentially containing mature or complex themes.

It is never too late to be an Oxford student! We are looking for the best students regardless of age and background. As a mature student you need to follow exactly the same application process as all other applicants.

By Jason Socrates Bardi Using a new technique that allows scientists to see the internal machinery of a living cell, a team of researchers at The Scripps Research Institute (TSRI) addressed one of the most fundamental issues in immune research: the early events in the immune system's recognition of foreign invaders, such as bacteria and viruses, in the body. In the latest issue of the journal Immunity, a team led by TSRI Associate Professor of Immunology Nicholas R.J. Gascoigne and Senior Research Associate Tomasz Zal used fluorescence resonance energy transfer (FRET) to look at the close interaction of immune molecules that recognize foreign antigens, which are small molecule markers that are components of the pathogens. Specifically, the researchers focused on the main receptor on the surface of mature T cells, called the T cell Receptor, and one important T cell surface "coreceptor" molecule, CD4. In particular, Zal and Gascoigne were interested in demonstrating vividly through FRET how other "antagonist" molecules in the bloodstream that can bind to the T cell receptor can block the interaction of the CD4 with the antigen, inhibit the signaling cascade that leads to T cell activation, and reduce the effectiveness of an immune response. "We can look at positions of [CD4 and T cell receptor] proteins and whether or not they are interacting," says Gascoigne. "That allows us to see whether or not you are getting T cell activation by a particular ligand—the very earliest events in T cell recognition," he adds. Recognition Key to Immune Response The immune system long ago evolved ways to recognize pathogenic invaders through their antigens. For instance, these antigens, or fragments of the pathogens, may come from pathogenic proteins that have been taken up and processed into small peptides a few amino acids long, which are then taken up by specialized antigen-presenting cells (APC). The APCs "present" the antigens on their surfaces by displaying them in molecular complexes with the so-called major histocompatibility complex (MHC) proteins. When a pathogen invades the immune system, APCs alert T cells by displaying the pathogenic antigens. When specific T cells see the antigen in the MHC, they generate a systemic immune response designed to lead to the destruction of the pathogen, starting with a cascade of internal activation events. The first event in this cascade is the positive recognition of the MHC and antigen peptide by the T cell receptor and coreceptors. The coreceptor is crucial for this recognition because it stabilizes the binding of the T cell receptor to the MHC. Once that positive recognition occurs, the T cells become activated as killer and helper T cells, aggressively destroying infected cells, stimulating an inflammatory response in infected tissue, and producing chemicals that induce other cells to make and release soluble antibodies that target the pathogen in the bloodstream. Such immune reaction regularly keeps us alive as we go through life in constant contact with the bacteria, viruses, and infectious microbes of the world. Significantly, the immune system has also evolved caution about activating its T cells. Excessive or inappropriate immune responses can be lethal to an organism, and so the cells of the immune system are highly discriminating in their ability to recognize foreign antigen and only foreign antigen. T cells can tell the difference between foreign peptide antigen and a "self" peptide that only differ by a single amino acid. That one amino acid makes all the difference. "The immune system can tell the difference," says Gascoigne, "and it makes a totally different response." However, the immune system can also be tricked into missing the foreign peptide when other molecules—antagonists—block the binding of the coreceptor to the MHC. Without this crucial step, the T cell will not become activated even if the T cell receptor sees the foreign antigen in the MHC. In Gascoigne and Zal's study, they use FRET to look at the recognition of MHC by the T cell receptor and the coreceptor CD4. They are able to see the interaction of MHC/CD4/T cell receptor live on the screen, and find that they can block this critical early event in immune recognition by adding antagonists. Fluorescence Resonance Energy Transfer Using FRET, scientists can now look at protein–protein interactions anywhere in a living cell in real time. FRET works on the same basis of traditional fluorescence microscopy, in which fluorophores—small molecules like green fluorescent protein (GFP) that absorb and reemit photons of a particular wavelength—are attached to proteins in the cell. One can then illuminate the cells with a monochromatic light source and train a microscope camera to capture the reemitted photons. In FRET, two different fluorescent molecules are used. Under the microscope, these two will have different emission wavelengths and therefore different colors, cyan and yellow, for instance. However, the emission wavelength of the cyan overlaps with the excitation of the yellow, and so when the two molecules are very close together, within 10 nanometers or so (a millionth of a centimeter), the cyan molecule will donate its energy to the yellow molecule, and yellow instead of cyan fluorescence will result. The new color indicates that the molecules to which the cyan and yellow fluorophors are attached are interacting. In the case of the Gascoigne lab's work, the CD4 molecules had yellow fluorescent protein attached, and part of the T cell receptor complex had a cyan fluorescent protein attached. When the CD4 and the T cell receptor are working properly and both recognizing the MHC, their two fluorescent proteins are close enough to interact, which is visible as reduced cyan fluorescence and increased yellow fluorescence upon exciting the cyan fluorophore under the microscope. And when T cell receptor antagonists are mixed in, there is no yellow fluorescence from the activation of the cyan protein, which would indicate that the fluorescent proteins—and therefore the CD4 molecules and the T cell receptors—are not interacting. The research article "Inhibition of T-cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse" is authored by Tomasz Zal, M. Anna Zal, and Nicholas R.J. Gascoigne and appears in the April 17, 2002 issue of Immunity. The research was funded by the National Institutes of Health and the Human Frontier Science Program Organization. TSRI scientists used a new technique to view the machinery of the immune system in action. A time-lapse movie shows interactions of A18.ZC.4Y cells with agonist loaded (1 mM) LK35 B cells. Click for a detailed scientific descrption of the video, which was provided courtesy of Cell Press.

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CEO of iQiyi Gong Yu says the website has established long-term and close relationships in the Asia-Pacific and America, and is now looking for new collaborations in Europe. China has around 500 million online video viewers, and over 60 percent of the content they watch is movies. The Chinese government has a quota system that limits the number of foreign films screened in Chinese cinemas, but so far it hasn't applied to online distribution.

Video websites like Youku Tudou have mature online marketing strategies and multimedia including trailers, documentaries and promotional music and videos made based on audiences' preferences. Their advantages in big data are also being used during the production of films. 041b061a72